Prof. Gozin Michael

  
Affiliation:School of chemistry
Shenkar Chemist building
room 106
Tel:  (972)-3-6405878
 
Fax: (972)-3-6405879
 
Email: cogozin@tau.ac.il
 
Personal Website:

 
Postal Address:School of chemistry
Tel Aviv University
Tel Aviv 69978

Research Interest

Formation and Characterization of Stable Protein Complexes with Fullerene and its Derivatives 

Over the past decade, research in the field of fullerene chemistry has greatly increased due to a wide range of potential applications proposed for fullerene-based materials. These applications span non-linear optical properties, superconductivity and the biological activity and, as industrial scale of fullerenes production approaches multi-ton level per year, the human and environmental exposure to the carbonaceous nanomaterials will be undoubtedly increased. While most of the current research is focused on examination of tissue- and cell-level nanomaterials influence, interaction on a molecular level, with native proteins, remains mostly unexplored.

As current research related to the toxicological and environmental effects of carbonaceous nanomaterials is still in its infancy, there is a rapidly growing public concern regarding the potential impact of these nanomaterials on human health and on environment. We believe that our research is very important as it lays a foundation for better understanding of carbonaceous materials bio-delivery systems and potential effects of these nanomaterials on environment and on human health. In addition we wish to understand how these compounds are interacting on molecular level with various native proteins and other biomolecules. Not less fascinating are the potential applications of these hybrid materials as crucial components in the future nano-bioelectronic devices, nano-sensors and artificial organs, functioning as the biocompatible interface between biological and electronic systems.

Selected Publications


  • "Fabrication and Properties of Nanodevices Based on Ferrocene-containing Molecules" Rosenberg, N.; Caster, A.; Gozin M.; Richter S., submitted.
  • "Interaction of [C60]-Fullerene and Carboxyfullerene with Proteins: Docking and Binding Site Alignment" Benyamini, H.; Shulman-Peleg, A.; Wolfson, H. J.; Belgorodsky, B.; Fadeev, L.; Gozin, M., submitted.
  • "Formation and Characterization of Stable Human Serum Albumin-Tris-malonic Acid [C60]-Fullerene Complex" Belgorodsky, B.; Fadeev, L.; Ittah, V.; Benyamini, H.; Zelner, S.; Huppert, D.; Kotlyar, A. B.; Gozin, M., Bioconjugate Chem. 2005, 16(5), 1058-1062.
  • "Construction of Dithiol-based Nanostructures by a Layer-exchange Process" Meshulam, G.; Rosenberg, N.; Caster, A.; Burstein, L.; Gozin M.; Richter S., Small 2005, 1(8-9), 848-851.
  • "Synthesis and Water Solubility of Adamantyl-OEG-fullerene Hybrids" A. Bar-Shir, Y. Engel, M. Gozin, J.Org. Chem., 2005, 70 (7),2660-2666.