Prof. Slutsky Inna

  
Affiliation:Sackler School of Medicine
Tel:  (972)-3-6406021
 
Fax: (972)-3-6409113
 
Email: islutsky@tau.ac.il
 
Personal Website:

 
Postal Address:Sackler School of Medicine
Tel Aviv University
Tel Aviv 69978

Research Interest

Information processing: From nano-scale single synapse to memory function

It is widely believed that memory is grounded in synaptic connections. However, the principles regulating encoding, storage and retrieval of information in synaptic networks remain elusive. Our research is focused on the endogenous mechanisms controlling memory capacity in adult brain. Our main target is to determine how the quality and quantity of ongoing neuronal activity affect the properties of individual pre- and post-synaptic compartments, neural connection (few synapses), synaptic network (thousands of synapses), and the whole system. To fulfill this goal, we are applying combination of electrophysiology, functional quantitative imaging, molecular biology, and behavioral techniques. Our recent results indicate that uncorrelated pattern of neuronal activity plays a key role in synaptic network organization and memory function.

Selected Publications


  • Slutsky, I., Wu, L.J., Li, B., Govindarajan, A., Zhuo, M., Tonegawa, S., Liu, G. Reversal of Memory Decline and Reconfiguration of Synaptic Network by Magnesium Ion (submitted).
  • Slutsky, I., Sadeghpour, S., Li, B., Liu, G. (2004). Enhancement of Synaptic Plasticity through Chronically Reduced Ca2 Flux during Uncorrelated Activity. Neuron 44: 835-849.
  • Slutsky, I., Wess, J., Gomeza, J., Dudel, J., Parnas, I., Parnas, H. (2003). Use of Knockout Mice Reveals Involvement of M2-Muscarinic Receptors in Control of the Kinetics of Acetylcholine Release. J. Neurophysiol. 89: 1954-1967.
  • Slutsky, I., Rashkovan, G. Parnas, H., Parnas, I. (2002). Ca2 -independent feedback inhibition of ACh release in the frog neuromuscular junction. J. Neurosci. 22, 3426-3433.