Dr. Perlson Eran

  
Affiliation:Physiology - Pharmacology, Sackler School of Medicine
Sackler School of Medicine building
Tel:  (972)-3-6408743
 
Email: eranpe@tau.ac.il
 
Personal Website:

 
Postal Address:Physiology - Pharmacology
Sackler School of Medicine

Tel Aviv University
Tel Aviv 69978

Research Interest

Nanomotors and microfluidic platforms reveal neurodegeneration mechanisms

Neuron cell death and synapse disruption seen in neurodegenerative diseases like ALS. It is a non-cell-autonomous process and involve a multi system progression. Neurons are highly polarized cells with very long axons. In order to maintain healthy and function properly the neurons depends on accurate and efficient long distance communication mechanism. Consequently, the precise targeting and delivery of cellular signals to specific, distinct sub-cellular compartments in neurons is largely achieved via axonal transport mechanisms.  Axonal transport is the cellular process of moving proteins, organelles, vesicles, RNA and other cellular factors to (retrograde) and from (anterograde) the neuron cell body. The molecular motor kinesin drives anterograde transport while the dynein motor drives the retrograde transport.


Vesicles live cell imaging reveals distinct mode of transport

We combine state of the art multidisciplinary approaches such as single molecule live imaging techniques and microfluid-co-culture chambers to understand basic mechanisms of axonal transport and motor proteins regulations and to elucidate the roles its play in:

  1. Cell survival
  2. Synapse stability


In-vitro microfluidic platform with motor neuron cell bodies on one side and muscle cells on the other, creating a powerful system to study axonal transport and neurodegeneration mechanisms

Selected Publications


  • Perlson, E., Hendricks, A., Holzbaur, E. Microtubule Tethering by Dynein and NCAM Facilitates Synaptic Stabilization. Revision in “Nature”.
  • Perlson, E., Maday, S., Fu, M., Moughamian, A., Holzbaur, E.(2010) Retrograde Axonal Transport: Pathways To Cell Death? Trends in Neuroscience. 33 (7), 335-44.
  • Hendricks, A .*/Perlson, E.*,. Ross, J.*, Schroeder, H., Tokito, M., Holzbaur, E. (2010) Motor coordination via tug-of war mechanism drives bidirectional vesicle transport. Current Biology. 20 (8), 697-702.

    *Equally contributing authors

  • Perlson, E., Jeong, GB., Ross, JL., Dixit, R., Wallace, KE., Kalb, RG., Holzbaur, EL. (2009) A Switch in Retrograde Signaling From Survival to Stress Leads to Rapid Onset Neurodegeneration. The Journal of Neuroscience 29 (31); 9903-9917.
  • Perlson, E., Holzbaur, EL. (2008) Myosin learns to recruit AMPA receptors. Cell 135 (3); 414-5.
  • Perlson, E., Holzbaur, EL. (2007) The Role of Molecular Motors in Axonal Transport. "Protein Trafficking in the Neuron" Andrew Bean editor. Elsevier Publishing.
  • Perlson, E., Hanz, S., Ben-Yaakov, K., Segal-Ruder, Y., Seger, R., Fainzilber, M. (2005) Vimentin dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 45 (5): 715-726.
  • Perlson, E., Medzihradszky, KF., Darula, Z., Munno, DW., Syed, NI., Burlingame, AL., Fainzilber, M. (2004) Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury. Mol Cell Proteomics. 3 (5): 510-20.
  • Hanz, S., Perlson, E., Willis, D., Huerta, J.J., Massarwa, R., Zheng, JQ, Kohler, M, van Minnen J., Koltzenburg, M., Twiss J.L., Fainzilber M., (2003) Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40: 1095-104.