Prof. Shaked Natan T.
|Affiliation:||Department Of Biomedical Engineering, Faculty of Engineering
|Postal Address:||Department of Biomedical Engineering|
Faculty of Engineering
Tel Aviv University
Tel Aviv 69978
Microscopic biological specimens, such as biological cells, are dynamic objects, continuously adjusting their three-dimensional sizes, shapes and other biophysical features. Microscopy and nanoscopy of these specimens can provide a powerful research tool for cell biology studies, as well as a means for medical diagnosis and monitoring of diseases. Many biological specimens, however, are mostly-transparent objects, and thus imaging them with conventional bright-field light microscopy fails to provide adequate image contrast. For this reason, exogenous contrast agents such as fluorescent labels are widely used in biomedical microscopy. However, these exogenous agents might be cytotoxic in the long run and there is a possibility that they will influence the specimen behavior. Additionally, fluorescent agents tend to photobleach, potentially limiting the imaging duration.