Lesman Ayelet

  
Affiliation:School Of Mechanical Engineering, Faculty of Engineering
Wolfson Mechanical Engineering building
room 331
Tel:  (972)-3-6408233
 
Email: ayeletlesman@tauex.tau.ac.il
 
Personal Website:

 
Postal Address:School of Mechanical Engineering
Faculty of Engineering

Tel Aviv University
Tel Aviv 69978

Research Interest

Biological cells are able to apply, sense and respond to mechanical forces which control their function. Cells also live in environments that exhibit unique mechanical properties with nonlinear elasticity and viscoelasticity. In our biomechanics laboratory at TAU Mechanical Engineering, we seek to understand how such cellular and environmental mechanical factors direct cells toward defined fates and organizations. We use experimental and numerical approaches to quantify the cell-induced material deformations, strains, and stresses throughout three-dimensional biomaterials (mainly hydrogels) during various biological processes including cell division, invasion and cell-cell interaction. Our research allows to better understand how cells interact with their microenvironment, knowledge that can be used to direct and control cell function for regenerative medicine applications.

Figure 1: (a) Quantification of cell-induced gel displacements using confocal microscopy
and digital volume correlation (DVC). The image shows 3D colored quivers of matrix displacements induced by a fibroblast cell in a fibrin gel. Each arrow is a vector indicating the direction of movement with the magnitude defined by the color bar. (b) Mechanical interaction between two cells (green) embedded in a fibrous gel (gray). Fibers of the gel condense and align between the cells due to cell contractility.

 

Selected Publications


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    1. Jacob Notbohm*, Ayelet Lesman*, David A. Tirrell, Guruswami Ravichandran. Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers. Integrative Biology. Oct 2015, 7(10):1186-95. *equal contribution
     
    2. Jacob Notbohm, Ayelet Lesman, Phoebus Rosakis, David A. Tirrell, Guruswami Ravichandran. Microbuckling of fibrin provides a mechanism for cell mechanosensing. Journal of the Royal Society Interface. July 2015, 12(108).
     
    3. Ayelet Lesman*, Jacob Notbohm*, David A. Tirrell, Guruswami Ravichandran. Contractile forces regulate cell division in three-dimensional environments. Journal of Cell Biology. Apr 2014, 205(2):155-62. *equal contribution
     
    4. Ayelet Lesman, Jacob Koffler, Roee Atlas, Yaron Blinder, Zvi Kam, Shulamit Levenberg. Engineering vessel-like networks within multicellular fibrin-based constructs. Biomaterials. Nov 2011, 32(31):7856-69.
     
    5. Ayelet Lesman, Yaron Blinder, Shulamit Levenberg. Modeling of flow-induced shear-stress within 3D cellular scaffold; Implications for vascular tissue-engineering. Biotechnology and Bioengineering. Feb 2010, 105(3):645-54.
     
    6. Ayelet Lesman*, Manhal Habib*, Amira Gepstein, Gil Arbel, Shulamit Levenberg and Lior Gepstein. Transplantation of tissue-engineered human vascularized cardiac muscle. Tissue Eng Part A. Jan 2010,16(1):115-25. *equal contribution
     
    7. Oren Caspi*, Ayelet Lesman*, Yaara Basevitch, Amira Gepstein, Gil Arbel, Manhal Habib, Lior Gepstein and Shulamit Levenberg. Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ. Res. Feb 2007, 100(2);263-272. *equal contribution