Prof. Korenstein Rafi
|Affiliation:||Physiology - Pharmacology, Sackler School of Medicine
|Postal Address:||Physiology - Pharmacology|
Sackler School of Medicine
Tel Aviv University
Tel Aviv 69978
Electrical enhancement of drug nano-carriers; Nanoscale cell membrane dynamics
The activity of research group in the field of nanoscience and nanotechnology addresses two main topics: (1) Electrical enhancement of delivery of nanoparticles carrying drugs into cells (electroendocytosis) and toxicology of nanoparticles; (2) Nanoscale dynamics of the cell surface of cells. In order to achieve more effective therapies while eliminating the potential for both under- and overdosing, we have developed a novel methodological platform to induce highly efficient transfer of specifically designed nanoparticles carrying drugs into cells. The method is based on exposure of cells to trains of low unipolar electric fields which leads to an efficient uptake of macromolecules and nanoparticles into cells. One application of this methodology is the treatment and cure of solid tumors in mice bearing different types of metastatic cancer.