Prof. Gershoni Jonathan

  
Affiliation:Department of Cell Research and Immunology
The Cohen Porter United Kingdom building
room 217
Tel:  (972)-3-6408981
 
Fax: (972)-3-6402046
 
Email: gershoni@tauex.tau.ac.il
 
Personal Website:

 
Postal Address:Department of Cell Research and Immunology
Tel Aviv University
Tel Aviv 69978

Research Interest

Nano-optical sensing of protein: Protein interactions

We work to elucidate the molecular mechanisms of bio-recognition, especially those related to the interplay between viruses and the immune system. Our main goals focus on understanding the specific interaction between viral proteins, their cognate receptors and the antibody response against them. The insights gained are applied towards the development of novel vaccines, therapeutics and immunodiagnostics. The latter aspect of our work incorporates the development of new optical biosensors. Spectral Reflectance Imaging Biosensing (SRIB) is a nanophotonic platform that supports multiplex protein arrays in which binding events are detected label-free. The schematic of the SRIB system used at Tel Aviv University and an explanation of SRIB principles are provided.

Selected Publications


  • Gershoni, J.M. 2008 Molecular decoys: antidotes, therapeutics and immunomodulators. Curr. Opin. Biotech. 19: 644-651.
  • Ozkumur, E, JW Needham, DA Bergstein, R Gonzalez, M Cabodi, J.M. Gershoni, BB Glodberg, MS Unlu 2008 Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications. Proc. Natl. Acad. Sci USA 105: 7988-7992.
  • Bergstein, DA, E Ozukumur, AC Wu, A Yalcin, JR Colson, JW Needham, RJ Irani, J.M. Gershoni, BB Goldberg, C DeLisi, MF Ruane, MS Unlu 2008 Resonant cavity Imaging: a means toward high thoughput label free protein detection Selec. Top. Quantum Electronics 14: 131139.
  • Gershoni J.M., A. Roitburd-Berman, D.D. Siman-Tov, N. Tarnovitski Freund, Y. Weiss 2007 Epitope mapping: the first step in eveloping epitope-based vaccines. BioDrugs 21: 1-12.
  • Bublil, E.M., N. Tarnovitski Freund, I. Mayrose, O. Penn, A. Roitburd-Berman, N.D. Rubinstein, T. Pupko, J.M. Gershoni 2007 Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope alghorithm. Proteins 68: 294-304.