Dr. Adler-Abramovich Lihi

Affiliation:Sackler School of Medicine
Department of Oral Biology, Green building
room 128
Tel:  (972)-3-6409066
Email: lihia@tauex.tau.ac.il
Personal Website:

Postal Address:Sackler School of Medicine
Tel Aviv University
Tel Aviv 69978

Research Interest

Selected Publications

  •  1. Berger, O., Yoskovitz, E., Adler-Abramovich, L., Gazit, E. Spectral transition in bio-inspired self-assembled peptide nucleic acid photonic crystals. Adv. Mater.; 2016.
    2. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt, J., Kesselman, E., Shimon, L. J.W., Ramamoorthy, A., Talmon, Y., Gazit, E. Spontaneous structural transition and crystal formation in minimal supramolecular polymer model. Sci. Adv.; 2016.
    3. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, T., Ebenstein, Y., Frolow, F., Shimon, L. J. W., Patolsky, F., Gazit, E. Light-emitting self-Assembled peptide nucleic acids exhibit both stacking and Watson-Crick base-pairing. Nature Nanotechnol.; 2015: 10: 353-360.
    4. Mondal, S.*, Adler-Abramovich, L.*, Lampel, A., Bram, Y., Lipstman, S., Gazit, E. Formation of functional super-helical assemblies by constrained single heptad repeat. Nature Commun.; 2015: 6, 8615.
    5. Pellach M., Atsmon-Raz Y., Simonovsky E., Gottlieb H., Jacoby G., Beck R., Adler-Abramovich, L., Miller Y., Gazit E. Spontaneous structural transition in phospholipid-inspired aromatic phosphopeptide nanostructures. ACS Nano; 2015: 9: 4085-4095.
    6. Tao, K., Adler-Abramovich, L., Gazit, E. Controllable Phase Separation by Boc-modified lipophilic acid as a multifunctional extractant. Sci. Rep.; 2015: 5, 17509
    7. De Luigi, A., Mariani, A., De Paola, M., Re Depaolini, A., Colombo, L., Russo, L., Rondelli, V., Brocca, P., Adler-Abramovich, L., Gazit, E., Del Favero, E., Cantù, L., Salmona. M. Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria. Sci. Rep.; 2015: 5
    8. Arnon, Z., Adler-Abramovich, L., Levin, A., Gazit E. Solvent-induced self-assembly of highly hydrophobic tetra-and pentaphenylalanine peptides. Isr. J. Chem.; 2015: 5, 756-762. 5.
    9. Shaham-Niv, S., Adler-Abramovich, L., Schnaider, L., Gazit E. Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies. Sci. Adv.; 2015: 1, e1500137.
    10. Tao, K., Yoskovitz, E., Adler-Abramovich, L., Gazit, E. Optical property modulation of Fmoc group by pH-dependent self-assembly. RSC Advances; 2015: 5, 73914-73918.
    11. Fichman, G., Guterman, T., Adler-Abramovich, L., Gazit, E. Synergetic functional properties of two-component single amino acid-based hydrogels. CrystEngComm.; 2015: 17, 8105-8112.
    12. Ostrov, N., Fichman, G., Adler-Abramovich, L., Gazit, E. FtsZ Cytoskeletal filaments as a template for metallic nanowire fabrication. J. Nanosci. Nanotechnol.; 2015: 15, 556-561.
    13. Adler-Abramovich, L., Gazit, E. The physical properties of supramolecular peptide assemblies: from building block association to technological applications. Chem. Soc. Rev.; 2014: 43, 6881-6893.
    14. Levin, A., Mason, T.O., Adler-Abramovich, L., Buell, A. K., Meisl, G., Galvagnion, C. Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers. Nature Commun.; 2014: 5, 5219.
    15. Fichman, G., Guterman, T., Adler-Abramovich, L., Gazit, E. The use of the calcitonin minimal recognition module for the design of DOPA-containing fibrillar assemblies. Nanomaterials; 2014: 4, 726-740.
    16. Fichman, G., Adler-Abramovich, L., Manohar, S., Mironi-Harpaz, I., Guterman, T. Seliktar, D., Messersmith, P.B., Gazit, E. Seamless metallic coating and surface adhesion of self-assembled bio-inspired nanostructures based on di-(3, 4-dihydroxy-L-phenylalanine) peptide motif. ACS Nano; 2014: 22, 7220-7228.
    17. Mossou, E., Teixeira, S.C.M., Mitchell, E.P., Mason, S.A., Adler-Abramovich, L., Gazit, E., Forsyth, V.T. The self-assembling zwitterionic form of L-phenylalanine at neutral pH. Acta Crystallogr., Sect. C.; 2014: 70, 326-331.
    18. Mason, T.O., Chirgadze, D.Y., Levin, A., Adler-Abramovich, L., Gazit, E., Knowles, T.P.J., Buell, A.K. Expanding the solvent chemical space for self-assembly of dipeptide nanostructures. ACS Nano; 2014: 8, 1243-1253.
    19. Azuri, I., Adler-Abramovich, L., Gazit, E., Hod, O., Kronik, L. Why are diphenylalanine-based peptide nanostructures so rigid? Insights from first principles calculations. J. Am. Chem. Soc.; 2014: 136, 963-969.
    20. Kaur, G., Adler-Abramovich, L., Gazit, E., Verma, S. Ultrastructure of metallopeptide-based soft spherical morphologies. R. Soc. Chem. Adv.; 2014: 4, 64457-64465.
    21. Ischakov, R., Adler-Abramovich, L., Buzhansky, L., Shekhter, T., Gazit, E. Peptide-based hydrogel nanoparticles as effective drug delivery agents. Bioorg. Med. Chem.; 2013: 21, 3517-3522.
    22. Ghosh, S., Adler-Abramovich, L., Gazit, E., Verma, S. Spacer driven morphological twist in Phe-Phe dipeptide conjugates. Tetrahedron; 2013: 69, 2004-2009.
    23. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Mango, A., Caflish, A., Frenkel, D., Gazit, E. Phenylalanine self-assembles into ordered toxic fibrils at phenylketonuria pathological concentration. Nature Chem. Biol.; 2012: 8, 701-706.
    24. Goldshtein, K.,  Golodnitsky, D., Peled, E., Adler-Abramovich, L., Gazit, E., Khatun, S., Stallworth, P., Greenbaum, S. Effect of peptide nanotube filler on structural and ion-transport properties of solid polymer electrolytes. Solid State Ion.; 2012: 220, 39-46.
    25. Roytman, R.*, Adler-Abramovich, L*, Kumar, K.S., Kuan, T.C., Lin, C.C., Gazit, E., Brik, A. Exploring the self-assembly of glycopeptides using a diphenylalanine scaffold. Org. Biomol. Chem.; 2011: 9, 5755-5761.
    26. Even N., Adler-Abramovich L., Buzhansky L., Dodiuk H. and Gazit E. Improvement of the mechanical properties of epoxy by peptide nanotube fillers. Small; 2011: 7, 1007-1011.
    27. Santhanamoorthi, N., Kolandaivel, P., Adler-Abramovich, L., Gazit, E., Filipek, S., Sowmya, V., Strzelczyk, A., Renugopalakrishnan, V. Diphenylalanine peptide nanotube: charge transport, band gap and its relevance to potential biomedical applications Adv. Mat. Lett.; 2011: 2, 100-105.
    28. Adler-Abramovich, L., and Gazit, E. Nanotubes and Nanowires, Self-assembled peptide nanostructures. Handbook of nanophysics; 2010: Vol. 4: Chapter 15.
    29. Orbach, R., Mironi-Harpaz, I., Adler-Abramovich, L., Mossou, E., Forsyth, T.V., Gazit, E., Seliktar, D. The rheological and structural properties of Fmoc-peptide-based hydrogels: The effect of aromatic molecular architecture on self-assembly and physical characteristics. Langmuir; 2010: 28, 2015-2022.
    30. Adler-Abramovich, L., Kol, N., Yanai, I., Barlam, D., Shneck Z.R., Gazit, E., Rousso, I. Self-assembled organic nanostructures with metallic-like tensile strength. Angew. Chem. Int. Ed.; 2010: 49, 9939-9942
    31. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E., Rishpon, J. Characterization of peptide nanostructures modified electrodes and their application in ultra-sensitive environmental monitoring. Small; 2010: 7, 825-831.
    32. Adler-Abramovich, L., Aronov, D., Beker, P., Yevnin, M., Stempler, S., Buzhansky, L., Rosenman, Gazit, E. Self-assembled arrays of peptide nanotubes by vapour deposition. Nature Nanotechnol.; 2009: 4, 849-854.
    33. Orbach, R., Adler-Abramovich, L., Zigerson, S., Mironi-Harpaz, I., Seliktar, D., Gazit, E. Self-assembled Fmoc-peptides as a platform for the formation of nanostructures and hydrogels. Biomacromolecules; 2009: 10, 2646-2651.
    34. Amdursky N, Molotskii M, Aronov D, Adler-Abramovich L, Gazit E, Rosenman G. Blue luminescence based on quantum confinement at peptide nanotubes. Nano Lett.; 2009: 9, 3111-3115.
    35. Tamamis, P.*, Adler-Abramovich, L.*, Reches, M., Marshall, K., Sikorski, P., Serpell, L., Gazit., E., Archontis, G. Self-assembly of phenylalanine oligopeptides: Insights from experiments and molecular dynamics simulations in implicit solvent. Biophys. J.; 2009: 96, 5020-5029.
    36. Adler-Abramovich, L., Aronov, D., Rosenman, G., Gazit, E. Patterned arrays of ordered peptide nanostructures. J. Nanosci. Nanotechnol.; 2009: 9, 1701-1708.
    37. Kasotakis, E., Mossou, E., Adler-Abramovich, L., Forsyth, T., Gazit E., Mitraki, A. Design of metal binding sites onto self-assembling peptide fibril scaffolds. Biopolymers; 2009: 92, 164-172.
    38. Adler-Abramovich, L., and Gazit, E. Controlled patterning of peptide nanotubes and nanospheres using inkjet printing technology. J. Pep. Sci.; 2008: 14, 217-223.
    39. Hill R. J. A., Sedman V. L., Allen S., Williams P., Paoli M., Adler-Abramovich L., Gazit E., Eaves L., Tendler S.J.B. Alignment of aromatic peptide tubes in strong magnetic fields. Adv. Mater.; 2007: 19, 4474-4479.
    40. Adler-Abramovich L., Perry R., Sagi A., Gazit E., Shabat D. Controlled assembly of peptide nanotubes triggered by enzymatic activation of self-immolative dendrimers. ChemBioChem.; 2007: 8, 859-862.
    41. Sedman, V.L., Adler-Abramovich, L., Allen, S., Gazit, E., Tendler, S.J.B. Direct observation of the release of phenylalanine from diphenylalanine nanotubes. J. Am. Chem. Soc.; 2006: 128, 6903-6908.
    42. Adler-Abramovich, L., Reches, M., Sedman, V.L., Tendler, S.J.B., Gazit, E. Notable thermal and chemical stability of diphenylalanine peptide nanotubes: Implications for nanotechnological applications. Langmuir; 2006: 22, 1313-1320.
    43. Kol, N.*, Adler-Abramovich, L.*, Barlam, D., Shneck Z.R., Gazit, E., Rousso, I. Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures. Nano Lett.; 2005: 5, 1343-1346.