Prof. Kotlyar Alexander

Affiliation:Biochemistry, The George S.Wise faculty of life sciences
Tel:  (972)-3-6407138
Fax: (972)-3-6406834
Personal Website:

Postal Address:Biochemistry
The George S.Wise faculty of life sciences

Tel Aviv University
Tel Aviv 69978

Research Interest

DNA – based Organic Nano Wires 

DNA is a fascinating soft material that naturally expresses two of the three main features required from molecular nanoelectronic components, namely recognition and specific structuring (sequence, length). The third additional property that is needed in order to implement DNA-derivatives for electrical device applications is conductivity. The central objective of this multidisciplinary project is, thus development of DNA-based conductive nanowires for nanoelectronics. There are two main goals of this the project. The first is to produce double-stranded [1,2], triple–stranded [3] and G4-DNA [4] molecular nanowires as well as complexes of the above wires with various redox active ions and to characterize their electrical properties.  We recently succeeded to produce for the first time a novel 4G-DNA nanowires that show encouraging conductivity signals while preserving the structuring and recognition qualities. The second goal of the project is development of model nanoelectronic devices on the basis of the above DNA-Based wires. Our strategy is to use specific alterations of the sequence and inclusions of hybrid inorganic elements to pre-planned locations in the conducting wire. A device resulting from this approach will be nanometric in size and embedded in the conducting wire itself. Finally we hope to establish first prototype single-DNA-based electronic devices. Several experimental and theoretical groups working in Israel and Europe are working as a team towards the realization of the goals of this interdisciplinary project. 

Selected Publications

  • A. Kotlyar, N. Borovok, T. Molotsky, L. Fadeev, M. Gozin, "In Vitro synthesis of uniform Poly(dG)-Poly(dC) by Klenow exo-fragment of Polymerase I.", Nucleic Acid Research 33, 525 (2005).
  • E. Shapir, J. Yi, H. Cohen, A. Kotlyar, G. Cuniberti, D. Porath, "The Puzzle of Contrast Inversion in DNA STM Imaging" , J. Phys. Chem. B 108, 14270 (2005).
  • A. Kotlyar, N. Borovok, T. Molotsky, D. Klinov, B. Dwir, E.Kapon "Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow Exo- fragment of DNA Polymerase I " Nucleic Acid Research (2005) in press.
  • A. Kotlyar, N. Borovok, T. Molotsky, H. Cohen, E. Shapir, D. Porath, "Novel Long Monomolecular G4-DNA Nanowires", Adv. Mater. 17, 1901 (2005).